Table 4

Direct cell-cell interactions between fibroblasts and other cell types

Cell type




Direct transfer (of FITC-dextran, mannose BSA gold) from macrophages to fibroblasts



Neutrophil adhesion to fibroblasts is increased by PMA treatment of neutrophils and by IL-1α


or TNF-α treatment of fibroblasts

Fibroblasts provide directional guidance to adhering neutrophils


PAF and IL-8 enhance neutrophil adhesion to and motility of adhered neutrophils along


fibroblasts, respectively, in an integrin β2 dependent process


Fibroblasts synthesize IL-1α, IL-1β, IL-6 and ICE


Fibroblast mediated synthesis of collagen type I and type III is decreased



Activated eosinophils adhere to fibroblasts: this adhesion is inhibited with RGDS


Mast cell

Formation of mast pseudopods and their translocation to fibroblast surface


Mast cell stimulates fibroblast proliferation after cell-cell contact in an IL-4 dependent manner


Gap junctions between the mast cell and fibroblast are possible


Osteoblast-like cells

Osteoblast-like cells stimulate fibroblast proliferation (regulation of osteoprogenitor cell



BSA, bovine serum albumen; ICE, interleukin-1β -converting enzyme; IL, interleukin; FITC, fluorescein isothiocyanate; PAF, platelet-activating factor; PMA, phorbol myristate acetate; RGDS, arginyl-glycyl-aspartyl-serine; TNF, tumor necrosis factor.

Konttinen et al. Arthritis Res 2000 2:348-355   doi:10.1186/ar111