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Bone loss: Therapeutic approaches for preventing bone loss in inflammatory arthritis

Qaiser Rehman and Nancy E Lane*

  • * Corresponding author: Nancy E Lane

Author Affiliations

University of California, San Francisco, CA, USA

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Arthritis Res Ther 2001, 3:221-227  doi:10.1186/ar305

Published: 18 May 2001


Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of rheumatoid arthritis, the prototype of inflammatory arthritis. Recent studies have highlighted the importance of receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast activation by inflammatory cells and subsequent bone loss. In this article, we review the pathogenesis of inflammatory bone loss and explore the possible therapeutic interventions to prevent it.

osteoclast; osteoprotegerin; receptor activator of nuclear factor-κB ligand; rheumatoid arthritis