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Open Badges Commentary

Current state of cartilage tissue engineering

Richard Tuli, Wan-Ju Li and Rocky S Tuan*

Author Affiliations

Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, USA

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Arthritis Res Ther 2003, 5:235-238  doi:10.1186/ar991

Published: 8 August 2003


Damage to cartilage is of great clinical consequence given the tissue's limited intrinsic potential for healing. Current treatments for cartilage repair are less than satisfactory, and rarely restore full function or return the tissue to its native normal state. The rapidly emerging field of tissue engineering holds great promise for the generation of functional cartilage tissue substitutes. The general approach involves a biocompatible, structurally and mechanically sound scaffold, with an appropriate cell source, which is loaded with bioactive molecules that promote cellular differentiation and/or maturation. This review highlights aspects of current progress in cartilage tissue engineering.

biomaterials; cartilage; mesenchymal progenitor cells; tissue engineering