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This article is part of the supplement: Global Arthritis Research Network (GARN): 4th World Congress on Arthritis in Montreal

Open Badges Oral presentation

A genetic analysis of lupus

AN Theofilopoulos

  • Correspondence: AN Theofilopoulos

Author Affiliations

Department of Immunology, The Scripps Research Institute, La Jolla, California, USA

Arthritis Res Ther 2004, 6(Suppl 3):17  doi:10.1186/ar1351

The electronic version of this article is the complete one and can be found online at:

Published:13 September 2004


Oral presentation

Systemic lupus erythematosus is a complex multigenic inherited disease with susceptibility determined by a combination of genetic, environmental and stochastic factors. Although not yet defined, recent technical advances have provided the means to dissect the component genetic contributions of polygenic traits. We have applied such approaches to mouse models of spontaneous systemic lupus erythematosus, and in this presentation I will summarize our genome-wide mapping studies that identified loci predisposing to several major lupus-related traits. Through the generation and study of interval congenic lines, precise mapping, and screening of candidate genes, identification of the specific genes and mechanisms associated with some of the major loci is currently being pursued.


The work of the authors reported herein was supported by National Institutes of Health grants AR39555 and AR30103.