Citrullination of collagen type II (CII) increases its arthritogenic properties. Lew.1AV1 rats developed disease with higher incidence (a) and earlier onset as well as a trend towards higher mean arthritic score among the affected animals (b) when immunised with citrullinated CII (Cit-CII) (open squares) than when immunised with unmodified CII (filled circles). Rats were immunised with Cit-CII or unmodified CII and monitored for signs of arthritis for the next 30 days. Incidence (a) and mean score of sick animals (b) were calculated. Data include 20 animals per group from two pooled experiments. *P < 0.05.
Lundberg et al. Arthritis Research & Therapy 2005 7:R458-R467 doi:10.1186/ar1697