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This article is part of the supplement: Basic science, rationale, background and future of abatacept

Highly Accessed Open Badges Review

The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis

Eric M Ruderman* and Richard M Pope

Author Affiliations

Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

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Arthritis Research & Therapy 2005, 7(Suppl 2):S21-S25  doi:10.1186/ar1688

Published: 16 March 2005


Abatacept (CTLA4–Ig) is a novel fusion protein designed to modulate the T cell co-stimulatory signal mediated through the CD28–CD80/86 pathway. Clinical trials have provided preliminary evidence of the efficacy of this compound in the treatment of rheumatoid arthritis. This review describes the molecular and biologic bases for the use of abatacept in rheumatoid arthritis and summarizes the current clinical data on its safety and effectiveness in this disease.