Experimental protocol for injection of HGF-HVJ liposomes into TSK/+ mice. Treatment consisted of once-weekly injection of either HGF-HVJ liposomes or control mock vector for a period of 8 weeks. Treatment was initiated at the age of 4 weeks. Histopathology and cytokine mRNA expression in the spleen, skin, and lungs was examined 8 weeks after treatment. HGF, hepatocyte growth factor; HVJ, hemagglutinating virus of Japan; im, intramuscular; TSK/+, tight skin.
Iwasaki et al. Arthritis Research & Therapy 2006 8:R161 doi:10.1186/ar2068