Dendritic cells are important directors of immune responsiveness. (a) Under steady-state conditions, recruitment of resting dendritic cell (DC) precursors into tissues and migration into secondary lymphoid organs occurs constitutively, and may favour tolerance induction. (b) On the other hand, stimulation of DC maturation and activation may initiate T-cell proinflammatory cytokine production, cytotoxic function, and B-cell antibody production.
Lutzky et al. Arthritis Research & Therapy 2007 9:219 doi:10.1186/ar2200