Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis
Universität Leipzig, IMISE/IKIT/BBZ, Johannisallee 30, 04109 Leipzig, Germany
Arthritis Research & Therapy 2007, 9:108 doi:10.1186/ar2313
See related research by Jacq et al., http://arthritis-research.com/content/9/4/R63 and related letter by Iikuni et al., http://arthritis-research.com/content/9/5/405Published: 31 October 2007
Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis (RA), Jacq and colleagues present a family-based, multi-stage, candidate gene association study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA (C-containing genotypes: odds ratio 1.94, confidence interval 1.3 to 2.9, P = 0.002). Support comes from a recent genome-wide study, which on its own would have missed identifying the association. Further research into the associating variant will require detailed haplotype analysis, verification in further studies, and research involving intermediate phenotypes or direct functional experiments. This new RA risk factor supports the role of angiogenesis in the disease.