Schematic diagram of the hierarchy and interplay between ET-1, TGF-β and CTGF. CTGF, connective tissue growth factor; ET, endothelin; NF-κB, nuclear factor-κB; TGF, transforming growth factor. Reproduced from  by permission of the publisher (Taylor & Francis Ltd, http://www.informaworld.com webcite).
Krieg et al. Arthritis Research & Therapy 2007 9(Suppl 2):S4 doi:10.1186/ar2188