Table 3

PTPN22 R620W polymorphism and links with immune diseases

Association identified

No association

Scleroderma: ATA positive and ACA positive

Multiple sclerosis

RA and JRA

Coeliac disease


Primary sclerosis cholangitis

Type I diabetes mellitus

Crohn's disease

Grave's and Addison's


Psoriatic arthritis

Ankylosing spondylitis

Wegener's granulomatosis

Primary Sjögren's syndrome

This area of research is reviewed by Gregersen and Batliwalla [18]. ACA, anticentromere antibody; ATA, antitopoisomerase antibody; JRA, juvenile rheumatoid arthritis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus.

Mayes and Trojanowska Arthritis Research & Therapy 2007 9(Suppl 2):S5   doi:10.1186/ar2189